[HTML][HTML] The divergent role of tumor necrosis factor receptors in infectious diseases

D Schlüter, M Deckert - Microbes and Infection, 2000 - Elsevier
Tumor necrosis factor (TNF) receptor types 1 and 2 are broadly expressed by most cell types
and are activated by binding of either TNF or lymphotoxin-β. TNF receptor-mediated immune
reactions are critically important in the pathogenesis and control of a variety of infections
caused by bacteria, viruses, protozoa, and fungi. This review summarizes recent findings on
the role of TNF receptors in infectious diseases and discusses the divergent functions of
these receptors in immune responses.