Osteopontin in cardiovascular disease: a potential therapeutic target
AH Waller, M Sanchez-Ross, E Kaluski… - Cardiology in …, 2010 - journals.lww.com
AH Waller, M Sanchez-Ross, E Kaluski, M Klapholz
Cardiology in Review, 2010•journals.lww.comOsteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted
phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a
multifunctional protein. OPN has been found to be expressed in various cell types and
species with many physiologic and pathologic functions. OPN has emerged as a potential
biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of
OPN in cardiovascular disease, specifically in vascular and valvular heart disease …
phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a
multifunctional protein. OPN has been found to be expressed in various cell types and
species with many physiologic and pathologic functions. OPN has emerged as a potential
biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of
OPN in cardiovascular disease, specifically in vascular and valvular heart disease …
Abstract
Osteopontin (OPN), also known as 44kDa bone phosphoprotein, sialoprotein I, secreted phosphoprotein I, 2ar, uropontin, and early T-lymphocyte activation-1 (Eta-1), is a multifunctional protein. OPN has been found to be expressed in various cell types and species with many physiologic and pathologic functions. OPN has emerged as a potential biomarker and mediator in cardiovascular disease. In this review, we will discuss the roles of OPN in cardiovascular disease, specifically in vascular and valvular heart disease, myocardial infarction and heart failure.
Lippincott Williams & Wilkins