Cationic liposome mediated transgene expression in the guinea pig cochlea

M Wareing, AN Mhatre, R Pettis, JJ Han, T Haut… - Hearing research, 1999 - Elsevier
Sensorineural hearing loss affects nearly 10% of the American population that is refractory
to conventional therapy. Gene therapy represents an intervention with potential therapeutic
efficacy. We studied the feasibility of cationic liposome mediated gene transfer within the
guinea pig cochlea in vivo following direct microinjection into the cochlea. Transgene
expression was persistent up to 14 days in the neurosensory epithelia and surrounding
tissue without toxicity and inflammation in the target organ. This study represents the first …