Use of indium-111-labeled cells in measurement of cellular dynamics of experimental cardiac allograft rejection
S OLUWOLE, T WANG, R FAWWAZ, K SATAKE… - …, 1981 - journals.lww.com
S OLUWOLE, T WANG, R FAWWAZ, K SATAKE, R NOWYGROD, K REEMTSMA…
Transplantation, 1981•journals.lww.comThis study evaluates the kinetics and utility of infused indium-111-labeled cells in detecting
rejection in ACI to Lewis rat heart allografts. Syngeneic leukocytes, lymph node
lymphocytes, and platelets were isolated and labeled with indium-111 (111 In) oxine,
respectively, and were infused iv into Lewis rats carrying beating ACI or syngeneic hearts
from post-transplant days 0 to 6. Recipients were imaged serially at 24 hr after infusion of
labeled cells followed by excision of both native and transplanted hearts for direct isotope …
rejection in ACI to Lewis rat heart allografts. Syngeneic leukocytes, lymph node
lymphocytes, and platelets were isolated and labeled with indium-111 (111 In) oxine,
respectively, and were infused iv into Lewis rats carrying beating ACI or syngeneic hearts
from post-transplant days 0 to 6. Recipients were imaged serially at 24 hr after infusion of
labeled cells followed by excision of both native and transplanted hearts for direct isotope …
Abstract
This study evaluates the kinetics and utility of infused indium-111-labeled cells in detecting rejection in ACI to Lewis rat heart allografts. Syngeneic leukocytes, lymph node lymphocytes, and platelets were isolated and labeled with indium-111 (111 In) oxine, respectively, and were infused iv into Lewis rats carrying beating ACI or syngeneic hearts from post-transplant days 0 to 6. Recipients were imaged serially at 24 hr after infusion of labeled cells followed by excision of both native and transplanted hearts for direct isotope count.
Lippincott Williams & Wilkins