[HTML][HTML] Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th17 lineage
Y Zhu, N Gumlaw, J Karman, H Zhao, J Zhang… - Journal of Biological …, 2011 - ASBMB
Lipid rafts reportedly have a role in coalescing key signaling molecules into the
immunological synapse during T cell activation, thereby modulating T cell receptor (TCR)
signaling activity. Recent findings suggest that a correlation may exist between increased
levels of glycosphingolipids (GSLs) in the lipid rafts of T cells and a heightened response of
those T cells toward activation. Here, we show that lowering the levels of GSLs in CD4+ T
cells using a potent inhibitor of glucosylceramide synthase (Genz-122346) led to a …
immunological synapse during T cell activation, thereby modulating T cell receptor (TCR)
signaling activity. Recent findings suggest that a correlation may exist between increased
levels of glycosphingolipids (GSLs) in the lipid rafts of T cells and a heightened response of
those T cells toward activation. Here, we show that lowering the levels of GSLs in CD4+ T
cells using a potent inhibitor of glucosylceramide synthase (Genz-122346) led to a …