[HTML][HTML] Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein AI pathway: 1-phenyl-2-decanoylamino-3-morpholino-1-propanol is a …
EN Glaros, WS Kim, CM Quinn, J Wong… - Journal of Biological …, 2005 - ASBMB
Cellular glycosphingolipid (GSL) storage is known to promote cholesterol accumulation.
Although physical interactions between GSLs and cholesterol are thought to cause
intracellular cholesterol" trapping," it is not known whether cholesterol homeostatic
mechanisms are also impaired under these conditions. ApoA-I-mediated cholesterol efflux
via ABCA1 (ATP-binding cassette transporter A1) is a key regulator of cellular cholesterol
balance. Here, we show that apoA-I-mediated cholesterol efflux was inhibited (by up to 53 …
Although physical interactions between GSLs and cholesterol are thought to cause
intracellular cholesterol" trapping," it is not known whether cholesterol homeostatic
mechanisms are also impaired under these conditions. ApoA-I-mediated cholesterol efflux
via ABCA1 (ATP-binding cassette transporter A1) is a key regulator of cellular cholesterol
balance. Here, we show that apoA-I-mediated cholesterol efflux was inhibited (by up to 53 …