[HTML][HTML] Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts
Z Fei, TK Bera, X Liu, L Xiang, I Pastan - Journal of Biological Chemistry, 2011 - ASBMB
We previously reported that partial disruption of the Ankrd26 gene in mice leads to
hyperphagia and leptin-resistant obesity. To determine whether the Ankrd26 mutation can
affect the development of adipocytes, we studied mouse embryo fibroblasts (MEFs) from the
mutant mice. We found that Ankrd26−/− MEFs have a higher rate of spontaneous
adipogenesis than normal MEFs and that adipocyte formation is greatly increased when the
cells are induced with troglitazone alone or with a mixture of troglitazone, insulin …
hyperphagia and leptin-resistant obesity. To determine whether the Ankrd26 mutation can
affect the development of adipocytes, we studied mouse embryo fibroblasts (MEFs) from the
mutant mice. We found that Ankrd26−/− MEFs have a higher rate of spontaneous
adipogenesis than normal MEFs and that adipocyte formation is greatly increased when the
cells are induced with troglitazone alone or with a mixture of troglitazone, insulin …
