Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis
M Pittelli, R Felici, V Pitozzi, L Giovannelli… - Molecular …, 2011 - Elsevier
During the last several years, evidence that various enzymes hydrolyze NAD into bioactive
products prompted scientists to revisit or design strategies able to increase intracellular
availability of the dinucleotide. However, plasma membrane permeability to NAD and the
mitochondrial origin of the dinucleotide still wait to be clearly defined. Here, we report that
intracellular NAD contents increased upon exposure of cell lines or primary cultures to
exogenous NAD (eNAD). NAD precursors could not reproduce the effects of eNAD, and they …
products prompted scientists to revisit or design strategies able to increase intracellular
availability of the dinucleotide. However, plasma membrane permeability to NAD and the
mitochondrial origin of the dinucleotide still wait to be clearly defined. Here, we report that
intracellular NAD contents increased upon exposure of cell lines or primary cultures to
exogenous NAD (eNAD). NAD precursors could not reproduce the effects of eNAD, and they …