[HTML][HTML] The transcription factor neural retina leucine zipper (NRL) controls photoreceptor-specific expression of myocyte enhancer factor Mef2c from an alternative …
H Hao, P Tummala, E Guzman, RS Mali… - Journal of Biological …, 2011 - ASBMB
Neural retina leucine zipper (NRL) is an essential transcription factor for cell fate
specification and functional maintenance of rod photoreceptors in the mammalian retina. In
the Nrl−/− mouse retina, photoreceptor precursors fail to produce rods and generate
functional cone photoreceptors that predominantly express S-opsin. Previous global
expression analysis using microarrays revealed dramatically reduced expression of myocyte
enhancer factor Mef2c in the adult Nrl−/− retina. We undertook this study to examine the …
specification and functional maintenance of rod photoreceptors in the mammalian retina. In
the Nrl−/− mouse retina, photoreceptor precursors fail to produce rods and generate
functional cone photoreceptors that predominantly express S-opsin. Previous global
expression analysis using microarrays revealed dramatically reduced expression of myocyte
enhancer factor Mef2c in the adult Nrl−/− retina. We undertook this study to examine the …