Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina

Y Ozawa, K Nakao, T Shimazaki, J Takeda… - Molecular and cellular …, 2004 - Elsevier
Ciliary neurotrophic factor (CNTF) has been known to inhibit the differentiation of
presumptive rod photoreceptor cells; however, the underlying mechanisms have remained
to be elucidated. We demonstrated that STAT3 activation, but not SHP2 activation, is
responsible for the CNTF/gp130 signaling that inhibits expression of Rhodopsin and its
upstream activator, crx, in the retinal explants derived from P0 mice (P0 retinal explants),
utilizing STAT3-deficient retina and electroporation of dominant-negative form of STAT3 …