The oxidation of lipoproteins has been proposed as a biological process that initiates and
accelerates arterial lesion development (1–5). Oxidized lipoproteins accumulate in lesions
(6) and may form at other inflammatory sites. Whether the oxidized lipoprotein is an initiator
or accelerator of disease is the subject of speculation, debate, and intensive study. Various
cellular and biochemical mediators of lipoprotein oxidation in vivo have been proposed, but
none has yet been proven to be responsible. Two decades ago we demonstrated that low …