[HTML][HTML] Impaired α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin
M Mandal, J Wei, P Zhong, J Cheng, LJ Duffney… - Journal of Biological …, 2011 - ASBMB
Emerging evidence from studies of Huntington disease (HD) pathophysiology suggests that
huntingtin (htt) and its associated protein HAP1 participate in intracellular trafficking and
synaptic function. However, it is largely unknown whether AMPA receptor trafficking, which is
crucial for controlling the efficacy of synaptic excitation, is affected by the mutant huntingtin
with polyglutamine expansion (polyQ-htt). In this study, we found that expressing polyQ-htt in
neuronal cultures significantly decreased the amplitude and frequency of AMPAR-mediated …
huntingtin (htt) and its associated protein HAP1 participate in intracellular trafficking and
synaptic function. However, it is largely unknown whether AMPA receptor trafficking, which is
crucial for controlling the efficacy of synaptic excitation, is affected by the mutant huntingtin
with polyglutamine expansion (polyQ-htt). In this study, we found that expressing polyQ-htt in
neuronal cultures significantly decreased the amplitude and frequency of AMPAR-mediated …