Critical periods during sensory development
N Berardi, T Pizzorusso, L Maffei - Current opinion in neurobiology, 2000 - Elsevier
N Berardi, T Pizzorusso, L Maffei
Current opinion in neurobiology, 2000•ElsevierRecent studies have made progress in characterizing the determinants of critical periods for
experience-dependent plasticity. They highlight the role of neurotrophins, NMDA receptors
and GABAergic inhibition. In particular, genetic manipulation of a single molecule, brain-
derived neurotrophic factor (BDNF), has been shown to alter the timing of the critical period
of plasticity in mouse visual cortex, establishing a causal relation between neurotrophin
action, the development of visual function, and the duration of the critical period.
experience-dependent plasticity. They highlight the role of neurotrophins, NMDA receptors
and GABAergic inhibition. In particular, genetic manipulation of a single molecule, brain-
derived neurotrophic factor (BDNF), has been shown to alter the timing of the critical period
of plasticity in mouse visual cortex, establishing a causal relation between neurotrophin
action, the development of visual function, and the duration of the critical period.
Recent studies have made progress in characterizing the determinants of critical periods for experience-dependent plasticity. They highlight the role of neurotrophins, NMDA receptors and GABAergic inhibition. In particular, genetic manipulation of a single molecule, brain-derived neurotrophic factor (BDNF), has been shown to alter the timing of the critical period of plasticity in mouse visual cortex, establishing a causal relation between neurotrophin action, the development of visual function, and the duration of the critical period.
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