One-carbon metabolism is a network of interrelated biochemical reactions that involve the
transfer of one-carbon groups from one compound to another. The coenzymes necessary for
several of these reactions include the B-vitamins, folate, vitamin B-12, vitamin B-6 and
riboflavin (vitamin B-2), whereas important intermediary compounds in this schema include
methionine and choline. There has been renewed interest in one-carbon metabolism during
the past several years, engendered by recent insights that indicate that modest dietary …