[HTML][HTML] The methyl-CpG-binding protein MeCP2 links DNA methylation to histone methylation
DNA methylation plays an important role in mammalian development and correlates with
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG
dinucleotides represents a major mechanism by which DNA methylation can repress
transcription. MeCP2 silences gene expression partly by recruiting histone deacetylase
(HDAC) activity, resulting in chromatin remodeling. Here, we show that MeCP2 associates
with histone methyltransferase activity in vivo and that this activity is directed against Lys 9 of …
chromatin-associated gene silencing. The recruitment of MeCP2 to methylated CpG
dinucleotides represents a major mechanism by which DNA methylation can repress
transcription. MeCP2 silences gene expression partly by recruiting histone deacetylase
(HDAC) activity, resulting in chromatin remodeling. Here, we show that MeCP2 associates
with histone methyltransferase activity in vivo and that this activity is directed against Lys 9 of …