Human T lymphocytes possess a limited in vitro life span
NL Perillo, RL Walford, MA Newman, RB Effros - Experimental gerontology, 1989 - Elsevier
The T lymphocyte offers certain theoretical advantages over other available cell types for the
study of aging. Immunosenescence is a well-established part of, and may be directly
relevant to, mammalian aging, and the T lymphocyte is well-characterized as to function, cell-
surface antigen make-up, and other factors. However, prior effors at studying in vitro aging of
T cells have been hampered by poor reproducibility in doubling potential and the
occurrence of a peculiar type of crisis. We have improved the culture conditions for long-term …
study of aging. Immunosenescence is a well-established part of, and may be directly
relevant to, mammalian aging, and the T lymphocyte is well-characterized as to function, cell-
surface antigen make-up, and other factors. However, prior effors at studying in vitro aging of
T cells have been hampered by poor reproducibility in doubling potential and the
occurrence of a peculiar type of crisis. We have improved the culture conditions for long-term …