[HTML][HTML] Cell fate plug and play: direct reprogramming and induced pluripotency
SM Chambers, L Studer - Cell, 2011 - cell.com
SM Chambers, L Studer
Cell, 2011•cell.comBuilding on the discovery that MyoD expression reprograms fibroblasts into muscle, three
papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the
reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors
without first passing the cells through a pluripotent state. Here we discuss the advantages
and challenges of harnessing this direct reprogramming method for regenerative medicine.
papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the
reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors
without first passing the cells through a pluripotent state. Here we discuss the advantages
and challenges of harnessing this direct reprogramming method for regenerative medicine.
Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.
cell.com