Nonantigen specific CD8+ T suppressor lymphocytes originate from CD8+ CD28− T cells and inhibit both T-cell proliferation and CTL function
G Filaci, M Fravega, S Negrini, F Procopio… - Human immunology, 2004 - Elsevier
Nonantigen specific CD8+ suppressor T lymphocytes (CD8+ Ts) inhibit T-cell proliferation of
antigen-specific T lymphocytes. The impossibility to generate in vitro these cells has been
correlated with the appearance of relapses in patients affected by autoimmune diseases,
suggesting the involvement of these cells in immune regulation. This study was aimed to
identify circulating precursors and to characterize the phenotype and mechanism of action of
CD8+ Ts. We found that CD8+ Ts can be generated in vitro from CD8+ CD28− T …
antigen-specific T lymphocytes. The impossibility to generate in vitro these cells has been
correlated with the appearance of relapses in patients affected by autoimmune diseases,
suggesting the involvement of these cells in immune regulation. This study was aimed to
identify circulating precursors and to characterize the phenotype and mechanism of action of
CD8+ Ts. We found that CD8+ Ts can be generated in vitro from CD8+ CD28− T …