Decline in CD28+ T cells in centenarians and in long-term T cell cultures: a possible cause for both in vivo and in vitro immunosenescence
RB Effros, N Boucher, V Porter, X Zhu… - Experimental …, 1994 - Elsevier
The dramatic decline in immune function with age, especially in T cell proliferative activity,
has been documented extensively in experimental animal models and in clinical studies of
the elderly. A similar proliferative decline is also seen in long-term T lymphocyte cultures
used to study in vitro cellular senescence. We have compared the peripheral blood T
lymphocytes of centenarians and younger controls for the cell surface expression of CD28, a
costimulatory molecule that is required for optimal activation and proliferation following …
has been documented extensively in experimental animal models and in clinical studies of
the elderly. A similar proliferative decline is also seen in long-term T lymphocyte cultures
used to study in vitro cellular senescence. We have compared the peripheral blood T
lymphocytes of centenarians and younger controls for the cell surface expression of CD28, a
costimulatory molecule that is required for optimal activation and proliferation following …