Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector/senescent T cells
R Tarazona, O DelaRosa, C Alonso, B Ostos… - Mechanisms of ageing …, 2001 - Elsevier
In humans, CD56, CD161, CD16, CD94 or CD57 represent prototypic markers of NK cells,
although they are also found on a subset of CD8+ T cells. We propose here that the
expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector
T cells that are expanded in vivo after antigenic activation leading to extensive proliferation.
The persistence of antigen will lead to loss of co-stimulatory molecules, telomere shortening
and defective IL-2 production, changes that define the state replicative senescence in T …
although they are also found on a subset of CD8+ T cells. We propose here that the
expression of NK receptors on CD8+ T cells can be considered a marker of cytotoxic effector
T cells that are expanded in vivo after antigenic activation leading to extensive proliferation.
The persistence of antigen will lead to loss of co-stimulatory molecules, telomere shortening
and defective IL-2 production, changes that define the state replicative senescence in T …