Role of intensive glucose control in development of renal end points in type 2 diabetes mellitus: systematic review and meta-analysis

SG Coca, F Ismail-Beigi, N Haq… - Archives of internal …, 2012 - jamanetwork.com
Background Aggressive glycemic control has been hypothesized to prevent renal disease in
patients with type 2 diabetes mellitus. A systematic review was conducted to summarize the
benefits of intensive vs conventional glucose control on kidney-related outcomes for adults
with type 2 diabetes. Methods Three databases were systematically searched (January 1,
1950, to December 31, 2010) with no language restrictions to identify randomized trials that
compared surrogate renal end points (microalbuminuria and macroalbuminuria) and clinical …