Sound conditioning reduces noise-induced permanent threshold shift in mice

N Yoshida, MC Liberman - Hearing research, 2000 - Elsevier
The phenomenon of conditioning-related protection, whereby prior exposure to moderate-
level, non-traumatic, sound protects the ear from subsequent traumatic exposure, has been
documented in a number of mammalian species. To probe the molecular mechanisms
underlying this effect, the mouse would be a useful model; however, a previous study
reported no conditioning effects in this species (Fowler et al., 1995). In our study, mice
(CBA/CaJ) were exposed to a traumatic octave-band noise (8–16 kHz at 100 dB SPL for 2 h) …