Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague–Dawley rat

WJ Wu, SH Sha, JD McLaren, K Kawamoto, Y Raphael… - Hearing research, 2001 - Elsevier
The availability of genetic information, transgenic and knock-out animals make the mouse a
primary model in biomedical research. Aminoglycoside ototoxicity, however, has rarely been
studied in mature mice because they are considered highly resistant to the drugs. This study
presents models for kanamycin ototoxicity in adult CBA/J, C57BL/6 and BALB/c mouse
strains and a comparison to Sprague–Dawley rats. Five-week-old mice were injected
subcutaneously twice daily with 400–900 mg kanamycin base/kg body weight for 15 days …