[PDF][PDF] Histological characterization of cutaneous nerve fibers containing gastrin-releasing peptide in NC/Nga mice: an atopic dermatitis model

T further examine whether GRP - Journal of Investigative …, 2009 - researchgate.net
T further examine whether GRP
Journal of Investigative Dermatology, 2009researchgate.net
Histological observations have shown that unmyelinated nerve fibers originating from dorsal
root ganglions are present at higher densities in the epidermis in several skin diseases such
as atopic dermatitis (AD), suggesting that hyperinnervation is partly responsible for
abnormal itch perception (Steinhoff et al., 2003b; Ikoma et al., 2006; Paus et al., 2006).
However, it has been difficult to histologically identify itch-specific fibers in the skin because
there have been no itch-specific markers available. Recently, a study of gastrin-releasing …
Histological observations have shown that unmyelinated nerve fibers originating from dorsal root ganglions are present at higher densities in the epidermis in several skin diseases such as atopic dermatitis (AD), suggesting that hyperinnervation is partly responsible for abnormal itch perception (Steinhoff et al., 2003b; Ikoma et al., 2006; Paus et al., 2006).
However, it has been difficult to histologically identify itch-specific fibers in the skin because there have been no itch-specific markers available. Recently, a study of gastrin-releasing peptide receptor (GRPR)-deficient mice has shown that the GRP/GRPR system is specifically involved in itch but not pain perception (Sun and Chen, 2007). Therefore, this study was conducted to immunohistochemically identify and characterize cutaneous nerve fibers containing GRP in NC/Nga mice using an AD model (Matsuda
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