RANKL-induced TRPV2 expression regulates osteoclastogenesis via calcium oscillations
H Kajiya, F Okamoto, T Nemoto, K Kimachi, K Toh-Goto… - Cell Calcium, 2010 - Elsevier
The receptor activator of NFκB ligand (RANKL) induces Ca2+ oscillations and activates the
Nuclear Factor of Activated T cells 1 (NFATc1) during osteoclast differentiation
(osteoclastogenesis). Ca2+ oscillations are an important trigger signal for
osteoclastogenesis, however the molecular basis of Ca2+ permeable influx pathways
serving Ca2+ oscillations has not yet been identified. Using a DNA microarray, we found that
Transient Receptor Potential Vanilloid channels 2 (TRPV2) are expressed significantly in …
Nuclear Factor of Activated T cells 1 (NFATc1) during osteoclast differentiation
(osteoclastogenesis). Ca2+ oscillations are an important trigger signal for
osteoclastogenesis, however the molecular basis of Ca2+ permeable influx pathways
serving Ca2+ oscillations has not yet been identified. Using a DNA microarray, we found that
Transient Receptor Potential Vanilloid channels 2 (TRPV2) are expressed significantly in …