Proteins that terminate with a consensus sequence known as CAAX undergo a series of
posttranslational modifications that include polyisoprenylation, endoproteolysis, and
carboxyl methylation. These modifications render otherwise hydrophilic proteins
hydrophobic at their C termini such that they associate with membranes. Whereas
prenylation occurs in the cytosol, postprenylation processing is accomplished on the
cytoplasmic surface of the endoplasmic reticulum and Golgi apparatus. Among the …