The roles of receptor and ligand endocytosis in regulating Notch signaling
R Le Borgne, A Bardin, F Schweisguth - 2005 - journals.biologists.com
R Le Borgne, A Bardin, F Schweisguth
2005•journals.biologists.comCell-cell signaling is a central process in the formation of multicellular organisms. Notch (N)
is the receptor of a conserved signaling pathway that regulates numerous developmental
decisions, and the misregulation of N has been linked to various physiological and
developmental disorders. The endocytosis of N and its ligands is a key mechanism by which
N-mediated cell-cell signaling is developmentally regulated. We review here the recent
findings that have highlighted the importance and complexity of this regulation.
is the receptor of a conserved signaling pathway that regulates numerous developmental
decisions, and the misregulation of N has been linked to various physiological and
developmental disorders. The endocytosis of N and its ligands is a key mechanism by which
N-mediated cell-cell signaling is developmentally regulated. We review here the recent
findings that have highlighted the importance and complexity of this regulation.
Cell-cell signaling is a central process in the formation of multicellular organisms. Notch (N) is the receptor of a conserved signaling pathway that regulates numerous developmental decisions, and the misregulation of N has been linked to various physiological and developmental disorders. The endocytosis of N and its ligands is a key mechanism by which N-mediated cell-cell signaling is developmentally regulated. We review here the recent findings that have highlighted the importance and complexity of this regulation.
journals.biologists.com