Classification of patients with common variable immunodeficiency by B cell secretion of IgM and IgG in response to anti-IgM and interleukin-2

A Bryant, NC Calver, E Toubi, ADB Webster… - Clinical immunology and …, 1990 - Elsevier
We have classified patients with common variable immunodeficiency (CVI) on the basis of
the ability of their B cells to respond to anti-IgM and interleukin (IL)-2 in vitro. Group A had
cells unable to secrete IgM or IgG, Group B secreted IgM alone, and Group C secreted both
IgM and IgG. A separate small group of patients lacked peripheral B cells. Where Ig
secretion was present with anti-IgM and IL-2, EBV increased it, but where it was absent, EBV
only induced IgM secretion in two out of eight Group A patients and IgG in one out of five …