[HTML][HTML] Altered complexin expression in psychiatric and neurological disorders: cause or consequence?
N Brose - Molecules and cells, 2008 - Elsevier
Complexins play a critical role in the control of fast synchronous neurotransmitter release.
They operate by binding to trimeric SNARE complexes consisting of the vesicle protein
Synaptobrevin and the plasma membrane proteins Syntaxin and SNAP-25, which are key
executors of membrane fusion reactions. SNARE complex binding by Complexins is thought
to stabilize and clamp the SNARE complex in a highly fusogenic state, thereby providing a
pool of readily releasable synaptic vesicles that can be released quickly and synchronously …
They operate by binding to trimeric SNARE complexes consisting of the vesicle protein
Synaptobrevin and the plasma membrane proteins Syntaxin and SNAP-25, which are key
executors of membrane fusion reactions. SNARE complex binding by Complexins is thought
to stabilize and clamp the SNARE complex in a highly fusogenic state, thereby providing a
pool of readily releasable synaptic vesicles that can be released quickly and synchronously …