Extracellular glutamate and other amino acids in experimental intracerebral hemorrhage: an in vivo microdialysis study
Critical care medicine, 2003•journals.lww.com
Objective To determine whether extracellular concentrations of glutamate and other amino
acids are significantly elevated after intracerebral hemorrhage and, if so, the temporal
characteristics of these changes. Although the role of excitotoxic amino acids, particularly
that of glutamate, has been described in ischemic stroke and head trauma, no information
exists regarding their possible contribution to the pathogenesis of neuronal injury in
intracerebral hemorrhage. Design
acids are significantly elevated after intracerebral hemorrhage and, if so, the temporal
characteristics of these changes. Although the role of excitotoxic amino acids, particularly
that of glutamate, has been described in ischemic stroke and head trauma, no information
exists regarding their possible contribution to the pathogenesis of neuronal injury in
intracerebral hemorrhage. Design
Abstract
Objective
To determine whether extracellular concentrations of glutamate and other amino acids are significantly elevated after intracerebral hemorrhage and, if so, the temporal characteristics of these changes. Although the role of excitotoxic amino acids, particularly that of glutamate, has been described in ischemic stroke and head trauma, no information exists regarding their possible contribution to the pathogenesis of neuronal injury in intracerebral hemorrhage.
Design
Lippincott Williams & Wilkins