Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome
J Czimmer, G Sütő, A Király, G Mózsik - Journal of Physiology-Paris, 2001 - Elsevier
Visceral hyperalgesia has been suggested to play a role in the development of symptoms
presented by irritable bowel syndrome patients. Otilonium bromide was developed to block
smooth muscle Ca release to control cramping pain of these patients. Aims: to determine
whether otilonium bromide can influence sensory thresholds of patients suffering from
irritable bowel syndrome. Methods: 15 patients with Rome-II positive IBS were tested by
Synectics Visceral Stimulator Barostat using rapid phasic distension (870 ml/min). The …
presented by irritable bowel syndrome patients. Otilonium bromide was developed to block
smooth muscle Ca release to control cramping pain of these patients. Aims: to determine
whether otilonium bromide can influence sensory thresholds of patients suffering from
irritable bowel syndrome. Methods: 15 patients with Rome-II positive IBS were tested by
Synectics Visceral Stimulator Barostat using rapid phasic distension (870 ml/min). The …