Adenosine kinase: exploitation for therapeutic gain
D Boison - Pharmacological reviews, 2013 - Elsevier
Abstract Adenosine kinase (ADK; EC 2.7. 1.20) is an evolutionarily conserved
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine-
monophosphate. This enzymatic reaction plays a fundamental role in determining the tone
of adenosine, which fulfills essential functions as a homeostatic and metabolic regulator in
all living systems. Adenosine not only activates specific signaling pathways by activation of
four types of adenosine receptors but it is also a primordial metabolite and regulator of …
phosphotransferase that converts the purine ribonucleoside adenosine into 5′-adenosine-
monophosphate. This enzymatic reaction plays a fundamental role in determining the tone
of adenosine, which fulfills essential functions as a homeostatic and metabolic regulator in
all living systems. Adenosine not only activates specific signaling pathways by activation of
four types of adenosine receptors but it is also a primordial metabolite and regulator of …