Chronic rotavirus infection in immunodeficiency

FT Saulsbury, JA Winkelstein, RH Yolken - The Journal of pediatrics, 1980 - Elsevier
FT Saulsbury, JA Winkelstein, RH Yolken
The Journal of pediatrics, 1980Elsevier
The characteristics of rotavirus infection in 23 children with a variety of primary
immunodeficiency diseases were studied. Stools and sera were tested for rotavirus by
means of the enzyme-linked immunosorbent assay and the enzyme-linked fluorescent
assay, respectively. Four immunodeficient patients had diarrhea during the study period and
all had rotavirus infection; rotavirus was not detected in the stools of the 19 asymptomatic
immunodeficient patients. Forty-six control children with diarrhea were tested and 22 had …
The characteristics of rotavirus infection in 23 children with a variety of primary immunodeficiency diseases were studied. Stools and sera were tested for rotavirus by means of the enzyme-linked immunosorbent assay and the enzyme-linked fluorescent assay, respectively. Four immunodeficient patients had diarrhea during the study period and all had rotavirus infection; rotavirus was not detected in the stools of the 19 asymptomatic immunodeficient patients. Forty-six control children with diarrhea were tested and 22 had rotavirus infection; rotavirus was not detected in 39 asymptomatic control children. One immunodeficient patient with X-linked agammaglobulinemia and one with severe combined immunodeficiency had chronic, symptomatic rotavirus infection with rotavirus excretion lasting more than six weeks. The other two immunodeficient patients and eight control children eliminated the rotavirus from their stools in periods ranging from two to 12 days. Rotavirus antigen was detected in the sera of three of the four immunodeficient patients; none of the 14 control infants tested had rotavirus antigen detected in their sera. This study indicates that rotavirus may produce a chronic infection in immunodeficient children.
Elsevier