[HTML][HTML] Amino acid substitutions in Gag protein at non-cleavage sites are indispensable for the development of a high multitude of HIV-1 resistance against protease …
H Gatanaga, Y Suzuki, H Tsang, K Yoshimura… - Journal of Biological …, 2002 - ASBMB
Amino acid substitutions in human immunodeficiency virus type 1 (HIV-1) Gag cleavage
sites have been identified in HIV-1 isolated from patients with AIDS failing chemotherapy
containing protease inhibitors (PIs). However, a number of highly PI-resistant HIV-1 variants
lack cleavage site amino acid substitutions. In this study we identified multiple novel amino
acid substitutions including L75R, H219Q, V390D/V390A, R409K, and E468K in the Gag
protein at non-cleavage sites in common among HIV-1 variants selected against the …
sites have been identified in HIV-1 isolated from patients with AIDS failing chemotherapy
containing protease inhibitors (PIs). However, a number of highly PI-resistant HIV-1 variants
lack cleavage site amino acid substitutions. In this study we identified multiple novel amino
acid substitutions including L75R, H219Q, V390D/V390A, R409K, and E468K in the Gag
protein at non-cleavage sites in common among HIV-1 variants selected against the …