A note on path-based variable selection in the penalized proportional hazards model

H Zou - Biometrika, 2008 - academic.oup.com
Biometrika, 2008academic.oup.com
We propose an efficient and adaptive shrinkage method for variable selection in the Cox
model. The method constructs a piecewise-linear regularization path connecting the
maximum partial likelihood estimator and the origin. Then a model is selected along the
path. We show that the constructed path is adaptive in the sense that, with a proper choice of
regularization parameter, the fitted model works as well as if the true underlying submodel
were given in advance. A modified algorithm of the least-angle-regression type efficiently …
Abstract
We propose an efficient and adaptive shrinkage method for variable selection in the Cox model. The method constructs a piecewise-linear regularization path connecting the maximum partial likelihood estimator and the origin. Then a model is selected along the path. We show that the constructed path is adaptive in the sense that, with a proper choice of regularization parameter, the fitted model works as well as if the true underlying submodel were given in advance. A modified algorithm of the least-angle-regression type efficiently computes the entire regularization path of the new estimator. Furthermore, we show that, with a proper choice of shrinkage parameter, the method is consistent in variable selection and efficient in estimation. Simulation shows that the new method tends to outperform the lasso and the smoothly-clipped-absolute-deviation estimators with moderate samples. We apply the methodology to data concerning nursing homes.
Oxford University Press