Contracting myocytes are highly variable in size and generally resemble elliptical cylinders
in shape. Although their arrangement within the ventricular wall is rather complex, their
length runs in a tangential manner, and their transverse axis runs transmurally.
Consequently, it was proposed many years ago that changes in myocyte length (L) may
contribute to chamber dilatation while myocyte transverse growth may be largely
responsible for wall thickening during cardiac hypertrophy. In recent years, the development …