[HTML][HTML] The adaptor protein β-arrestin2 enhances endocytosis of the low density lipoprotein receptor
JH Wu, K Peppel, CD Nelson, FT Lin, TA Kohout… - Journal of Biological …, 2003 - ASBMB
Endocytosis of the low density lipoprotein (LDL) receptor (LDLR) in coated pits employs the
clathrin adaptor protein ARH. Similarly, agonist-dependent endocytosis of heptahelical
receptors in coated pits employs the clathrin adaptor β-arrestin proteins. In mice fed a high
fat diet, we found that homozygous deficiency of β-arrestin2 increased total and LDL plus
intermediate-density lipoprotein cholesterol levels by 23 and 53%, respectively (p< 0.05),
but had no effect on high density lipoprotein cholesterol levels. We therefore tested whether …
clathrin adaptor protein ARH. Similarly, agonist-dependent endocytosis of heptahelical
receptors in coated pits employs the clathrin adaptor β-arrestin proteins. In mice fed a high
fat diet, we found that homozygous deficiency of β-arrestin2 increased total and LDL plus
intermediate-density lipoprotein cholesterol levels by 23 and 53%, respectively (p< 0.05),
but had no effect on high density lipoprotein cholesterol levels. We therefore tested whether …