Inhibition of lysyl oxidase and prolyl hydroxylase activity in glucorcorticoid treated rats

SC Benson, PA LuValle - Biochemical and biophysical research …, 1981 - Elsevier
SC Benson, PA LuValle
Biochemical and biophysical research communications, 1981Elsevier
Triamcinolone diacetate produced a dose dependent decrease in lysyl oxidase activity in
the skin of new born rats when administered over a three day period. Maximum inhibition by
this glucorticoid resulted in less than 10% of control lysyl oxidase activity. A similar though
less dramatic effect was observed on skin prolyl hydroxylase activity. These results suggest
that the antianabolic effect of glucocorticoids on collagen synthesis extend to enzymes
involved in the intra-and extracellular modifications of collagen.
Abstract
Triamcinolone diacetate produced a dose dependent decrease in lysyl oxidase activity in the skin of new born rats when administered over a three day period. Maximum inhibition by this glucorticoid resulted in less than 10% of control lysyl oxidase activity. A similar though less dramatic effect was observed on skin prolyl hydroxylase activity. These results suggest that the antianabolic effect of glucocorticoids on collagen synthesis extend to enzymes involved in the intra- and extracellular modifications of collagen.
Elsevier