The “Great Obstetrical Syndromes” are associated with disorders of deep placentation

I Brosens, R Pijnenborg, L Vercruysse… - American journal of …, 2011 - Elsevier
Defective deep placentation has been associated with a spectrum of complications of
pregnancy including preeclampsia, intrauterine growth restriction, preterm labor, preterm
premature rupture of membranes, late spontaneous abortion, and abruptio placentae. The
disease of the placental vascular bed that underpins these complications is commonly
investigated with targeted biopsies. In this review, we critically evaluate the biopsy technique
to summarize the salient types of defective deep placentation, and propose criteria for the …