Differential processing of class-I-restricted epitopes by the standard proteasome and the immunoproteasome
BJ Van den Eynde, S Morel - Current opinion in immunology, 2001 - Elsevier
BJ Van den Eynde, S Morel
Current opinion in immunology, 2001•ElsevierUpon exposure to IFN-γ, the standard proteasome is replaced by the immunoproteasome,
which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing
antigenic peptides presented to CD8+ T cells. This view has been challenged this year by
reports showing that some epitopes, mainly of self origin, are not processed by the
immunoproteasome and that mature dendritic cells constitutively express
immunoproteasomes and therefore cannot efficiently present such epitopes.
which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing
antigenic peptides presented to CD8+ T cells. This view has been challenged this year by
reports showing that some epitopes, mainly of self origin, are not processed by the
immunoproteasome and that mature dendritic cells constitutively express
immunoproteasomes and therefore cannot efficiently present such epitopes.
Upon exposure to IFN-γ, the standard proteasome is replaced by the immunoproteasome, which contains LMP2, LMP7 and MECL1, and is considered more efficient at producing antigenic peptides presented to CD8+ T cells. This view has been challenged this year by reports showing that some epitopes, mainly of self origin, are not processed by the immunoproteasome and that mature dendritic cells constitutively express immunoproteasomes and therefore cannot efficiently present such epitopes.
Elsevier