[HTML][HTML] Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element: cross-talk between basic helix-loop-helix/per-Arnt-Sim …

SL Woods, ML Whitelaw - Journal of Biological Chemistry, 2002 - ASBMB
The basic helix-loop-helix/Per-Arnt-Sim homology (bHLH/PAS) protein family comprises a
group of transcriptional regulators that often respond to a variety of developmental and
environmental stimuli. Two murine members of this family, Single Minded 1 (SIM1) and
Single Minded 2 (SIM2), are essential for postnatal survival but differ from other prototypical
family members such as the dioxin receptor (DR) and hypoxia-inducible factors, in that they
behave as transcriptional repressors in mammalian one-hybrid experiments and have yet to …