[HTML][HTML] CD38 plays a role in effective containment of mycobacteria within granulomata and polarization of Th1 immune responses against Mycobacterium avium
MS Viegas, A do Carmo, T Silva, F Seco, V Serra… - Microbes and …, 2007 - Elsevier
CD38 is a multifunctional ectoenzyme that behaves either as an enzyme, a cell adhesion
molecule or as a cell surface receptor involved in cell signalling. It is expressed in cells of
several lineages, including B and T lymphocytes, and macrophages. CD38 was shown to be
important for the development of T-cell dependent humoral immune responses against
extracellular pathogens. It also appears to be functionally important in macrophages, which
are the host cells of Mycobacterium avium, an intracellular parasite that survives within these …
molecule or as a cell surface receptor involved in cell signalling. It is expressed in cells of
several lineages, including B and T lymphocytes, and macrophages. CD38 was shown to be
important for the development of T-cell dependent humoral immune responses against
extracellular pathogens. It also appears to be functionally important in macrophages, which
are the host cells of Mycobacterium avium, an intracellular parasite that survives within these …