[HTML][HTML] Presenilin-dependent “γ-secretase” processing of deleted in colorectal cancer (DCC)
Y Taniguchi, SH Kim, SS Sisodia - Journal of Biological Chemistry, 2003 - ASBMB
The presenilin-γ-secretase complex plays a critical role in mediating intramembranous
proteolysis of several type I membrane proteins, including β-amyloid precursor protein (APP)
and Notch. We now show that deleted in colorectal cancer (DCC) is subject to proteolysis
within the ectodomain segment both in cultured cells and in vivo and that the residual
membrane-tethered DCC" stub" is subsequently processed by γ-secretase to generate a
derivative termed DCC-intracellular domain (ICD). The production of DCC-ICD is inhibited …
proteolysis of several type I membrane proteins, including β-amyloid precursor protein (APP)
and Notch. We now show that deleted in colorectal cancer (DCC) is subject to proteolysis
within the ectodomain segment both in cultured cells and in vivo and that the residual
membrane-tethered DCC" stub" is subsequently processed by γ-secretase to generate a
derivative termed DCC-intracellular domain (ICD). The production of DCC-ICD is inhibited …