BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis
K Basso, R Dalla-Favera - Advances in immunology, 2010 - Elsevier
BCL6 is a transcriptional repressor which has emerged as a critical regulator of germinal
centers (GC), the sites where B cells are selected based on the production of antibodies with
high affinity for the antigen. BCL6 is also a frequently activated oncogene in the
pathogenesis of human B cell lymphomas, most of which derive from the GC B cells. A
thorough understanding of the biological role of BCL6 in normal B cell development and
lymphomagenesis depends upon the identification of the full set of genes that are targets of …
centers (GC), the sites where B cells are selected based on the production of antibodies with
high affinity for the antigen. BCL6 is also a frequently activated oncogene in the
pathogenesis of human B cell lymphomas, most of which derive from the GC B cells. A
thorough understanding of the biological role of BCL6 in normal B cell development and
lymphomagenesis depends upon the identification of the full set of genes that are targets of …