[HTML][HTML] Redundant control of adipogenesis by histone deacetylases 1 and 2

M Haberland, M Carrer, MH Mokalled… - Journal of Biological …, 2010 - ASBMB
Adipocyte differentiation is a well defined process that is under the control of transcriptional
activators and repressors. We show that histone deacetylase (HDAC) inhibitors efficiently
block adipocyte differentiation in vitro. This effect is specific to adipogenesis, as another
mesenchymal differentiation process, osteoblastogenesis, is enhanced upon HDAC
inhibition. Through the systematic genetic deletion of HDAC genes in cultured mesenchymal
precursor cells, we show that deletion of HDAC1 and HDAC2 leads to reduced lipid …