Complement in lupus nephritis: the good, the bad, and the unknown
L Bao, RJ Quigg - Seminars in nephrology, 2007 - Elsevier
The complement system consists of 3 pathways and more than 30 proteins, including those
with biological activity that directly or indirectly mediate the effects of this system, plus a set
of regulatory proteins necessary to prevent injudicious complement activation on host tissue.
The role for complement in the pathogenesis of systemic lupus erythematosus (SLE) is
paradoxic. On one hand, the complement system appears to have protective features in that
hereditary homozygous deficiencies of classic pathway components are associated with an …
with biological activity that directly or indirectly mediate the effects of this system, plus a set
of regulatory proteins necessary to prevent injudicious complement activation on host tissue.
The role for complement in the pathogenesis of systemic lupus erythematosus (SLE) is
paradoxic. On one hand, the complement system appears to have protective features in that
hereditary homozygous deficiencies of classic pathway components are associated with an …