Structural and functional relationships of the steroid hormone receptors' N-terminal transactivation domain

R Kumar, G Litwack - Steroids, 2009 - Elsevier
Steroid hormone receptors are members of a family of ligand inducible transcription factors,
and regulate the transcriptional activation of target genes by recruiting coregulatory proteins
to the pre-initiation machinery. The binding of these coregulatory proteins to the steroid
hormone receptors is often mediated through their two activation functional domains, AF1,
which resides in the N-terminal domain, and the ligand-dependent AF2, which is localized in
the C-terminal ligand-binding domain. Compared to other important functional domains of …