[HTML][HTML] AMPK and exercise: glucose uptake and insulin sensitivity

HM O'neill - Diabetes & metabolism journal, 2013 - synapse.koreamed.org
Diabetes & metabolism journal, 2013synapse.koreamed.org
AMPK is an evolutionary conserved sensor of cellular energy status that is activated during
exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation,
mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and
contribute to the development of insulin resistance. AMPK deficient mouse models have
been used to provide direct genetic evidence either supporting or refuting a role for AMPK in
regulating these processes. Exercise promotes glucose uptake by an insulin dependent …
AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).
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