Dampening insulin signaling by an NLRP3'meta-flammasome'
AMK Choi, K Nakahira - Nature immunology, 2011 - nature.com
AMK Choi, K Nakahira
Nature immunology, 2011•nature.comThe inflammasome has been linked to metabolic disorders such as obesity and type 2
diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy
critically mediates cytoplasmic receptor NLRP3–dependent activation of the inflammasome
by the saturated fatty acids contained in a high-fat diet.
diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy
critically mediates cytoplasmic receptor NLRP3–dependent activation of the inflammasome
by the saturated fatty acids contained in a high-fat diet.
The inflammasome has been linked to metabolic disorders such as obesity and type 2 diabetes. Data now suggest that the crosstalk between the inflammasome and autophagy critically mediates cytoplasmic receptor NLRP3–dependent activation of the inflammasome by the saturated fatty acids contained in a high-fat diet.
nature.com