Inhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugs
G Pilon, P Dallaire, A Marette - Journal of Biological Chemistry, 2004 - ASBMB
AMP-activated protein kinase (AMPK), an energy-sensing enzyme that is activated in
response to cellular stress, is a critical signaling molecule for the regulation of multiple
metabolic processes. AMPK has recently emerged as an attractive novel target for the
treatment of obesity and type 2 diabetes because its activation increases fatty acid oxidation
and improves glucose homeostasis. Here we show that pharmacological activation of AMPK
by insulin-sensitizing drugs markedly inhibits inducible nitric-oxide synthase (iNOS), a …
response to cellular stress, is a critical signaling molecule for the regulation of multiple
metabolic processes. AMPK has recently emerged as an attractive novel target for the
treatment of obesity and type 2 diabetes because its activation increases fatty acid oxidation
and improves glucose homeostasis. Here we show that pharmacological activation of AMPK
by insulin-sensitizing drugs markedly inhibits inducible nitric-oxide synthase (iNOS), a …
